Ser25
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Home > Phosphorylation Site Page: > Ser25  -  FBXW7 (human)

Site Information
sLRGNPSssQVDEEQ   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 25126710

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry (in vitro) ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Kinases, in vitro:
PLK2 (human) ( 1 )

Downstream Regulation
Effects of modification on FBXW7:
protein degradation ( 1 )
Effects of modification on biological processes:
cytoskeletal reorganization ( 1 )

References 

1

Cizmecioglu O, et al. (2012) Plk2 regulates centriole duplication through phosphorylation-mediated degradation of Fbxw7 (human Cdc4). J Cell Sci 125, 981-92
22399798   Curated Info