Ser176
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Home > Phosphorylation Site Page: > Ser176  -  FBXW7 (human)

Site Information
KRKLDHGsEVRSFSL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 25126709

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry (in vitro) ( 2 ) , mutation of modification site ( 1 , 2 ) , western blotting ( 2 )
Disease tissue studied:
breast cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
ERK1 (human) ( 1 ) , ERK2 (mouse) ( 1 ) , PLK2 (human) ( 2 )
Kinases, in vitro:
ERK1 (human) ( 1 ) , ERK2 (human) ( 1 ) , PLK2 (human) ( 2 )
Treatments:
aphidicolin ( 2 ) , U0126 ( 1 )

Downstream Regulation
Effects of modification on FBXW7:
molecular association, regulation ( 1 ) , protein degradation ( 2 )
Effects of modification on biological processes:
cytoskeletal reorganization ( 2 )
Induce interaction with:
Myc (human) ( 1 )

References 

1

Shu L, et al. (2022) NRG1 regulates Fra-1 transcription and metastasis of triple-negative breast cancer cells via the c-Myc ubiquitination as manipulated by ERK1/2-mediated Fbxw7 phosphorylation. Oncogene 41, 907-919
34992218   Curated Info

2

Cizmecioglu O, et al. (2012) Plk2 regulates centriole duplication through phosphorylation-mediated degradation of Fbxw7 (human Cdc4). J Cell Sci 125, 981-92
22399798   Curated Info