Thr122
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Home > Phosphorylation Site Page: > Thr122  -  TRF1 (human)

Site Information
LTACQLRtIYICQFL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2481000

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mutation of modification site ( 1 , 2 ) , western blotting ( 1 )
Disease tissue studied:
breast cancer ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
CK2A1 (human) ( 2 )
Kinases, in vitro:
CK2A1 (human) ( 2 )
Treatments:
DRB ( 2 ) , siRNA ( 2 )

Downstream Regulation
Effects of modification on TRF1:
intracellular localization ( 2 ) , molecular association, regulation ( 2 ) , protein stabilization ( 1 , 2 )
Induce interaction with:
CK2B (human) ( 2 ) , DNA ( 1 , 2 ) , TRF1 (human) ( 2 )

References 

1

Yoo JE, Park YN, Oh BK (2014) PinX1, a telomere repeat-binding factor 1 (TRF1)-interacting protein, maintains telomere integrity by modulating TRF1 homeostasis, the process in which human telomerase reverse Transcriptase (hTERT) plays dual roles. J Biol Chem 289, 6886-98
24415760   Curated Info

2

Kim MK, et al. (2008) Regulation of telomeric repeat binding factor 1 binding to telomeres by casein kinase 2-mediated phosphorylation. J Biol Chem 283, 14144-52
18347021   Curated Info