Tyr92
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Home > Phosphorylation Site Page: > Tyr92  -  GRK2 (human)

Site Information
FyEEIKKyEkLETEE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 456873

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 , 3 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
Src (human) ( 1 , 3 )
Treatments:
carbachol ( 1 ) , isoproterenol ( 3 )

Downstream Regulation
Effects of modification on GRK2:
molecular association, regulation ( 1 ) , protein degradation ( 3 )
Induce interaction with:
G-alpha(q) (human) ( 1 )

References 

1

Mariggi├▓ S, et al. (2006) Tyrosine phosphorylation of G-protein-coupled-receptor kinase 2 (GRK2) by c-Src modulates its interaction with Galphaq. Cell Signal 18, 2004-12
16725308   Curated Info

2

Wu JH, et al. (2005) The platelet-derived growth factor receptor-beta phosphorylates and activates G protein-coupled receptor kinase-2. A mechanism for feedback inhibition. J Biol Chem 280, 31027-35
15994317   Curated Info

3

Penela P, Elorza A, Sarnago S, Mayor F (2001) Beta-arrestin- and c-Src-dependent degradation of G-protein-coupled receptor kinase 2. EMBO J 20, 5129-38
11566877   Curated Info