Tyr92
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Home > Phosphorylation Site Page: > Tyr92  -  GRK2 (cow)

Site Information
FyEEIKKyEKLETEE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 456873

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
breast cancer ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , SKBr3 (breast cell) ( 1 )

Upstream Regulation
Regulatory protein:
Src (human) ( 1 )
Putative in vivo kinases:
EGFR (human) ( 1 ) , Src (human) ( 1 )
Kinases, in vitro:
EGFR (human) ( 1 )
Treatments:
AG1478 ( 1 ) , DPDPE ( 1 ) , EGF ( 1 ) , PP2 ( 1 )

Downstream Regulation
Effects of modification on GRK2:
enzymatic activity, induced ( 1 )

References 

1

Chen Y, et al. (2008) EGF Transregulates Opioid Receptors through EGFR-mediated GRK2 Phosphorylation and Activation. Mol Biol Cell 19, 2973-83
18463167   Curated Info

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