Thr177
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Home > Phosphorylation Site Page: > Thr177  -  CDK6 (human)

Site Information
YSFQMALtSVVVTLW   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2454600

In vivo Characterization
Methods used to characterize site in vivo:
2D analysis ( 1 )
Disease tissue studied:
colorectal cancer ( 1 ) , colorectal carcinoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Kinases, in vitro:
CDK7 (human) ( 1 , 2 )
Treatments:
1NM-PP1 ( 1 ) , serum ( 1 )

References 

1

Bisteau X, et al. (2013) CDK4 T172 Phosphorylation Is Central in a CDK7-Dependent Bidirectional CDK4/CDK2 Interplay Mediated by p21 Phosphorylation at the Restriction Point. PLoS Genet 9, e1003546
23737759   Curated Info

2

Bockstaele L, et al. (2006) Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors". Mol Cell Biol 26, 5070-85
16782892   Curated Info