Tyr249
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Home > Phosphorylation Site Page: > Tyr249  -  RXRA (human)

Site Information
VEPKTETyVEANMGL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 456812

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 )
Disease tissue studied:
prostate cancer ( 1 )
Relevant cell line - cell type - tissue:
COS (fibroblast) ( 2 ) , RWPE1 (prostate cell) ( 1 ) , RWPE2 (prostate cell) ( 1 )

Upstream Regulation
Kinases, in vitro:
MKK4 (human) ( 2 )
Treatments:
1,25_dihydroxyvitamin_D ( 1 )

Downstream Regulation
Effects of modification on RXRA:
activity, inhibited ( 2 )
Effects of modification on biological processes:
transcription, altered ( 2 ) , transcription, inhibited ( 1 )

References 

1

Zhang Z, et al. (2010) Constitutive activation of the mitogen-activated protein kinase pathway impairs vitamin D signaling in human prostate epithelial cells. J Cell Physiol 224, 433-42
20432439   Curated Info

2

Lee HY, et al. (2000) Stress pathway activation induces phosphorylation of retinoid X receptor. J Biol Chem 275, 32193-9
10938283   Curated Info

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