Ser32
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Home > Phosphorylation Site Page: > Ser32  -  RXRA (human)

Site Information
RGsMAAPsLHPSLGP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 456811

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 2 ) , mutation of modification site ( 1 , 2 ) , phosphoamino acid analysis ( 2 )
Disease tissue studied:
prostate cancer ( 1 )
Relevant cell line - cell type - tissue:
COS (fibroblast) ( 2 ) , RWPE1 (prostate cell) ( 1 ) , RWPE2 (prostate cell) ( 1 )

Upstream Regulation
Treatments:
1,25_dihydroxyvitamin_D ( 1 ) , As2O3 ( 2 )

Downstream Regulation
Effects of modification on RXRA:
activity, inhibited ( 2 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:
transcription, inhibited ( 1 , 2 )
Inhibit interaction with:
SRC-1 (human) ( 1 )

References 

1

Zhang Z, et al. (2010) Constitutive activation of the mitogen-activated protein kinase pathway impairs vitamin D signaling in human prostate epithelial cells. J Cell Physiol 224, 433-42
20432439   Curated Info

2

Mann KK, et al. (2005) Arsenic trioxide inhibits nuclear receptor function via SEK1/JNK-mediated RXRalpha phosphorylation. J Clin Invest 115, 2924-33
16184197   Curated Info

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