Ser505

Site Information
MAKERAHstAsHsss SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 456807

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 2 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:	293 (epithelial) ( 1 ) , MKN-45 (gastric) ( 2 ) , S.cerevisiae ( 1 )

Upstream Regulation
Putative in vivo kinases:	PKACA (human) ( 1 )
Treatments:	cicaprost ( 1 ) , Go_6983 ( 1 ) , H-89 ( 1 ) , KT5720 ( 1 ) , R01138452 ( 1 )

Downstream Regulation
Effects of modification on PDZK1:	molecular association, regulation ( 1 )
Effects of modification on biological processes:	cell growth, induced ( 1 ) , cell motility, induced ( 1 )
Induce interaction with:	PTGIR (human) ( 1 )

References
1	Turner EC, Mulvaney EP, Reid HM, Kinsella BT (2011) Interaction of the human prostacyclin receptor with the PDZ adapter protein PDZK1: role in endothelial cell migration and angiogenesis. Mol Biol Cell 22, 2664-79 21653824 Curated Info
2	Rush J (2008) CST Curation Set: 4491; Year: 2008; Biosample/Treatment: cell line, MKN-45/untreated &'\|\|' normal; Disease: gastric carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-Akt Substrate (RXRXXS/T) (110B7) Rabbit mAb Cat#: 9614, PTMScan(R) Phospho-Akt Substrate Motif (RXXS/T) Immunoaffinity Beads Cat#: 1978 Curated Info

References

Turner EC, Mulvaney EP, Reid HM, Kinsella BT (2011) Interaction of the human prostacyclin receptor with the PDZ adapter protein PDZK1: role in endothelial cell migration and angiogenesis. Mol Biol Cell 22, 2664-79
21653824 Curated Info

Rush J (2008) CST Curation Set: 4491; Year: 2008; Biosample/Treatment: cell line, MKN-45/untreated &'||' normal; Disease: gastric carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-Akt Substrate (RXRXXS/T) (110B7) Rabbit mAb Cat#: 9614, PTMScan(R) Phospho-Akt Substrate Motif (RXXS*/T*) Immunoaffinity Beads Cat#: 1978
Curated Info