Ser744
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Home > Phosphorylation Site Page: > Ser744  -  Caldesmon (human)

Site Information
GLKVGVSsRINEWLT   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 456707

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 )
Relevant cell line - cell type - tissue:
A7r5 ('muscle, smooth') ( 1 )

Upstream Regulation
Kinases, in vitro:
PAK2 (human) ( 2 )

Downstream Regulation
Effects of modification on biological processes:
cell motility, altered ( 1 , 2 ) , cytoskeletal reorganization ( 1 )

References 

1

Jiang Q, Huang R, Cai S, Wang CL (2010) Caldesmon regulates the motility of vascular smooth muscle cells by modulating the actin cytoskeleton stability. J Biomed Sci 17, 6
20128924   Curated Info

2

Eppinga RD, et al. (2006) Requirement of reversible caldesmon phosphorylation at P21-activated kinase-responsive sites for lamellipodia extensions during cell migration. Cell Motil Cytoskeleton 63, 543-62
16800003   Curated Info