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Home > Phosphorylation Site Page: > Ser702  -  Caldesmon (chicken)

Site Information
GLKVGVSsRINEWLT   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 456707

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry (in vitro) ( 2 )

Upstream Regulation
Kinases, in vitro:
PAK3 (human) ( 1 ) , PAK3 (mouse) ( 3 ) , smMLCK (human) ( 2 )

Downstream Regulation
Effects of modification on Caldesmon:
molecular association, regulation ( 1 )
Inhibit interaction with:
Calmodulin (human) ( 1 )



Hamden SS, Schroeter MM, Chalovich JM (2010) Phosphorylation of caldesmon at sites between residues 627 and 642 attenuates inhibitory activity and contributes to a reduction in Ca2+-calmodulin affinity. Biophys J 99, 1861-8
20858431   Curated Info


Sobieszek A, Sarg B, Lindner H, Seow CY (2010) Phosphorylation of caldesmon by myosin light chain kinase increases its binding affinity for phosphorylated myosin filaments. Biol Chem 391, 1091-104
20536391   Curated Info


Foster DB, et al. (2000) Phosphorylation of caldesmon by p21-activated kinase. Implications for the Ca(2+) sensitivity of smooth muscle contraction. J Biol Chem 275, 1959-65
10636898   Curated Info