Ser702
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Home > Phosphorylation Site Page: > Ser702  -  Caldesmon (chicken)

Site Information
GLKVGVSsRINEWLT   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 456707

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry (in vitro) ( 2 )

Upstream Regulation
Kinases, in vitro:
PAK3 (human) ( 1 ) , PAK3 (mouse) ( 3 ) , smMLCK (human) ( 2 )

Downstream Regulation
Effects of modification on Caldesmon:
molecular association, regulation ( 1 )
Inhibit interaction with:
Calmodulin (human) ( 1 )

References 

1

Hamden SS, Schroeter MM, Chalovich JM (2010) Phosphorylation of caldesmon at sites between residues 627 and 642 attenuates inhibitory activity and contributes to a reduction in Ca2+-calmodulin affinity. Biophys J 99, 1861-8
20858431   Curated Info

2

Sobieszek A, Sarg B, Lindner H, Seow CY (2010) Phosphorylation of caldesmon by myosin light chain kinase increases its binding affinity for phosphorylated myosin filaments. Biol Chem 391, 1091-104
20536391   Curated Info

3

Foster DB, et al. (2000) Phosphorylation of caldesmon by p21-activated kinase. Implications for the Ca(2+) sensitivity of smooth muscle contraction. J Biol Chem 275, 1959-65
10636898   Curated Info