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Site Information |
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TSVyESPySDPEELK SwissProt Entrez-Gene |
Blast this site against: NCBI SwissProt PDB |
Site Group ID: 447587 |
In vivo Characterization | |
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Methods used to characterize site in vivo: | |
Disease tissue studied: | |
Relevant cell line - cell type - tissue: |
Upstream Regulation | |
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Regulatory protein: | |
Putative in vivo kinases: | |
Putative upstream phosphatases: | |
Phosphatases, in vitro: | |
Treatments: |
Downstream Regulation | |
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Effects of modification on ZAP70: | |
Effects of modification on biological processes: |
References | |
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Poirier A, et al. (2024) The induction of SHP-1 degradation by TAOK3 ensures the responsiveness of T cells to TCR stimulation. Sci Signal 17, eadg4422
38166031 Curated Info |
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Gaud G, et al. (2023) CD3ζ ITAMs enable ligand discrimination and antagonism by inhibiting TCR signaling in response to low-affinity peptides. Nat Immunol 24, 2121-2134
37945821 Curated Info |
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Choi S, et al. (2023) THEMIS increases TCR signaling in CD4CD8 thymocytes by inhibiting the activity of the tyrosine phosphatase SHP1. Sci Signal 16, eade1274
37159521 Curated Info |
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Schmied L, et al. (2023) SHP-1 localization to the activating immune synapse promotes NK cell tolerance in MHC class I deficiency. Sci Signal 16, eabq0752
37040441 Curated Info |
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Horkova V, et al. (2023) Unique roles of co-receptor-bound LCK in helper and cytotoxic T cells. Nat Immunol 24, 174-185
36564464 Curated Info |
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Sridaran D, et al. (2022) Inhibiting ACK1-mediated phosphorylation of C-terminal Src kinase counteracts prostate cancer immune checkpoint blockade resistance. Nat Commun 13, 6929
36376335 Curated Info |
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Kästle M, et al. (2022) Type of PaperY192 within the SH2 Domain of Lck Regulates TCR Signaling Downstream of PLC-γ1 and Thymic Selection. Int J Mol Sci 23
35806279 Curated Info |
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Damen H, et al. (2022) Negative Regulation of Zap70 by Lck Forms the Mechanistic Basis of Differential Expression in CD4 and CD8 T Cells. Front Immunol 13, 935367
35860252 Curated Info |
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Ko JS, et al. (2021) Ssu72 phosphatase directly binds to ZAP-70, thereby providing fine-tuning of TCR signaling and preventing spontaneous inflammation. Proc Natl Acad Sci U S A 118
34452999 Curated Info |
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Sripada A, et al. (2021) Sprouty2 positively regulates T cell function and airway inflammation through regulation of CSK and LCK kinases. PLoS Biol 19, e3001063
33684096 Curated Info |
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Driessens G, et al. (2011) Beta-catenin inhibits T cell activation by selective interference with linker for activation of T cells-phospholipase C-γ1 phosphorylation. J Immunol 186, 784-90
21149602 Curated Info |
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Deswal S, Schulze AK, Höfer T, Schamel WW (2011) Quantitative analysis of protein phosphorylations and interactions by multi-colour IP-FCM as an input for kinetic modelling of signalling networks. PLoS One 6, e22928
21829558 Curated Info |
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Cemerski S, et al. (2008) The balance between T cell receptor signaling and degradation at the center of the immunological synapse is determined by antigen quality. Immunity 29, 414-22
18760640 Curated Info |
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Maksumova L, et al. (2007) Differential function of PTPalpha and PTPalpha Y789F in T cells and regulation of PTPalpha phosphorylation at Tyr-789 by CD45. J Biol Chem 282, 20925-32
17507376 Curated Info |
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Zipfel PA, Zhang W, Quiroz M, Pendergast AM (2004) Requirement for Abl kinases in T cell receptor signaling. Curr Biol 14, 1222-31
15268851 Curated Info |