Lys599
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Home > Acetylation Site Page: > Lys599  -  NRF2 (human)

Site Information
FLVPkSKkPDVKKN_   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 23940021

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
leukemia ( 1 ) , chronic myelogenous leukemia ( 1 ) , liver cancer ( 1 )
Relevant cell line - cell type - tissue:
HepG2 (hepatic) ( 1 ) , K562 (erythroid) ( 1 )

Upstream Regulation
Treatments:
nicotinamide ( 1 ) , resveratrol ( 1 ) , selisistat ( 1 ) , trichostatin_A ( 1 )

Downstream Regulation
Effects of modification on NRF2:
intracellular localization ( 1 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:
transcription, induced ( 1 )
Induce interaction with:
DNA ( 1 )

References 

1

Kawai Y, et al. (2011) Acetylation-deacetylation of the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) regulates its transcriptional activity and nucleocytoplasmic localization. J Biol Chem 286, 7629-40
21196497   Curated Info

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