Ser108
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Home > Phosphorylation Site Page: > Ser108  -  RCAN1 (rat)

Site Information
PDKQFLIsPPAsPPV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 456022

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 , 3 ) , mutation of modification site ( 1 , 4 )
Relevant cell line - cell type - tissue:
'brain, brainstem' ( 2 ) , 'brain, cerebellum' ( 2 ) , 'brain, cerebral cortex' ( 2 ) , adipose tissue ( 2 ) , heart ( 2 ) , intestine ( 2 ) , kidney ( 2 ) , liver ( 2 , 3 ) , lung ( 2 ) , muscle ( 2 ) , myocyte-heart ( 4 ) , neuron-'brain, hippocampus' ( 1 ) , spleen ( 2 ) , stomach ( 2 ) , testis ( 2 ) , thymus ( 2 )

Upstream Regulation
Putative in vivo kinases:
GSK3B (rat) ( 1 )

Downstream Regulation
Effects of modification on RCAN1:
enzymatic activity, induced ( 1 )
Effects of modification on biological processes:
neural plasticity ( 1 )

References 

1

Dudilot A, Trillaud-Doppia E, Boehm J (2020) RCAN1 Regulates Bidirectional Synaptic Plasticity. Curr Biol 30, 1167-1176.e2
32084406   Curated Info

2

Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876
22673903   Curated Info

3

Demirkan G, et al. (2011) Phosphoproteomic Profiling of In Vivo Signaling in Liver by the Mammalian Target of Rapamycin Complex 1 (mTORC1). PLoS One 6, e21729
21738781   Curated Info

4

Liu Q, Busby JC, Molkentin JD (2009) Interaction between TAK1-TAB1-TAB2 and RCAN1-calcineurin defines a signalling nodal control point. Nat Cell Biol 11, 154-61
19136967   Curated Info

5

Abbasi S, et al. (2005) The essential role of MEKK3 signaling in angiotensin II-induced calcineurin/nuclear factor of activated T-cells activation. J Biol Chem 280, 36737-46
16126726   Curated Info

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