Tyr1337
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Home > Phosphorylation Site Page: > Tyr1337  -  Ron (mouse)

Site Information
yVQLTAAyVNVGPRA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 456488

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , BaF3 ('B lymphocyte, precursor') ( 2 ) , MEL (erythroid) ( 2 )

Upstream Regulation
Treatments:
MSP ( 2 )

Downstream Regulation
Effects of modification on Ron:
enzymatic activity, induced ( 1 )
Effects of modification on biological processes:
apoptosis, induced ( 2 ) , cell growth, altered ( 2 )
Induce interaction with:
GRB2 (mouse) ( 2 ) , PIK3CA (mouse) ( 2 ) , PLCG1 (mouse) ( 2 ) , SHC1 (mouse) ( 2 )

References 

1

Wei X, Ni S, Correll PH (2005) Uncoupling ligand-dependent and -independent mechanisms for mitogen-activated protein kinase activation by the murine Ron receptor tyrosine kinase. J Biol Chem 280, 35098-107
16103119   Curated Info

2

Iwama A, Yamaguchi N, Suda T (1996) STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family. EMBO J 15, 5866-75
8918464   Curated Info

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