Tyr1353
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Home > Phosphorylation Site Page: > Tyr1353  -  Ron (human)

Site Information
SALLGDHyVQLPATy   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 456487

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 3 ) , mutation of modification site ( 2 , 3 ) , phospho-antibody ( 1 , 2 , 3 ) , western blotting ( 1 , 2 , 3 )
Disease tissue studied:
breast cancer ( 1 )
Relevant cell line - cell type - tissue:
3T3 (fibroblast) ( 2 ) , COS (fibroblast) ( 3 ) , MCF-10A (breast cell) ( 1 )

Upstream Regulation
Regulatory protein:
MSP (human) ( 1 )
Putative in vivo kinases:
Met (human) ( 3 )

Downstream Regulation
Effects of modification on Ron:
molecular association, regulation ( 3 ) , phosphorylation ( 2 )
Effects of modification on biological processes:
cell growth, altered ( 2 )
Induce interaction with:
Met (human) ( 3 )

References 

1

Feres KJ, Ischenko I, Hayman MJ (2009) The RON receptor tyrosine kinase promotes MSP-independent cell spreading and survival in breast epithelial cells. Oncogene 28, 279-88
18836480   Curated Info

2

Santoro MM, et al. (2000) The Ron oncogenic activity induced by the MEN2B-like substitution overcomes the requirement for the multifunctional docking site. Oncogene 19, 5208-11
11064459   Curated Info

3

Follenzi A, et al. (2000) Cross-talk between the proto-oncogenes Met and Ron. Oncogene 19, 3041-9
10871856   Curated Info

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