Ser65
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Home > Phosphorylation Site Page: > Ser65  -  PIN1 (human)

Site Information
sHLLVkHsQSRRPss   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 456481

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 ) , mutation of modification site ( 2 )
Relevant cell line - cell type - tissue:
HeLa (cervical) ( 2 )

Upstream Regulation
Putative in vivo kinases:
PLK1 (human) ( 2 )
Kinases, in vitro:
PLK1 (human) ( 2 )

Downstream Regulation
Effects of modification on PIN1:
protein stabilization ( 2 )

References 

1

Ando K, et al. (2013) Tau pathology modulates Pin1 post-translational modifications and may be relevant as biomarker. Neurobiol Aging 34, 757-69
22926167   Curated Info

2

Eckerdt F, et al. (2005) Polo-like kinase 1-mediated phosphorylation stabilizes Pin1 by inhibiting its ubiquitination in human cells. J Biol Chem 280, 36575-83
16118204   Curated Info

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