Thr299
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Home > Phosphorylation Site Page: > Thr299  -  IkB-alpha (human)

Site Information
EsEFTEFtEDELPyD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 456335

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 2 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Kinases, in vitro:
CK2A1 (human) ( 1 , 2 )

Downstream Regulation
Effects of modification on IkB-alpha:
protein degradation ( 2 )

References 

1

Shen J, Channavajhala P, Seldin DC, Sonenshein GE (2001) Phosphorylation by the protein kinase CK2 promotes calpain-mediated degradation of IkappaBalpha. J Immunol 167, 4919-25
11673497   Curated Info

2

Lin R, et al. (1996) Phosphorylation of IkappaBalpha in the C-terminal PEST domain by casein kinase II affects intrinsic protein stability. Mol Cell Biol 16, 1401-9
8657113   Curated Info