Tyr187
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Home > Phosphorylation Site Page: > Tyr187  -  PKCD (human)

Site Information
WGLNkQGyKCRQCNA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447579

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
brain cancer ( 1 , 2 ) , glioblastoma ( 2 ) , glioma ( 1 , 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
virus infection ( 2 )

Downstream Regulation
Effects of modification on PKCD:
activity, inhibited ( 2 ) , phosphorylation ( 1 )
Effects of modification on biological processes:
apoptosis, altered ( 2 ) , apoptosis, induced ( 1 )

References 

1

Lomonaco SL, et al. (2008) Phosphorylation of protein kinase Cdelta on distinct tyrosine residues induces sustained activation of Erk1/2 via down-regulation of MKP-1: role in the apoptotic effect of etoposide. J Biol Chem 283, 17731-9
18434324   Curated Info

2

Zrachia A, et al. (2002) Infection of glioma cells with Sindbis virus induces selective activation and tyrosine phosphorylation of protein kinase C delta. Implications for Sindbis virus-induced apoptosis. J Biol Chem 277, 23693-701
11927579   Curated Info