Ser541
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Home > Phosphorylation Site Page: > Ser541  -  SCN8A (human)

Site Information
NRIGRKFsIMNQsLL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 23142148

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 ) , mutation of modification site ( 1 ) , phosphopeptide mapping ( 1 )
Disease tissue studied:
esophageal cancer, surrounding tissue ( 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , esophagus ( 2 ) , ND7/23 ('neuron, dorsal root ganglion') ( 1 )

Upstream Regulation
Putative in vivo kinases:
CAMK2A (human) ( 1 )
Treatments:
KN-92 ( 1 ) , KN-93 ( 1 )

References 

1

Zybura AS, et al. (2020) CaMKII enhances voltage-gated sodium channel Nav1.6 activity and neuronal excitability. J Biol Chem
32611770   Curated Info

2

Tucker M (2009) CST Curation Set: 7082; Year: 2009; Biosample/Treatment: tissue, esophagus/untreated; Disease: esophageal cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info