Ser27
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Home > Phosphorylation Site Page: > Ser27  -  CRMP-2 iso3 (human)

Site Information
FKNLGsGsPKPRQKF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 23053573

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
breast cancer ( 2 , 6 ) , lung cancer ( 4 , 6 ) , non-small cell lung cancer ( 6 ) , non-small cell lung adenocarcinoma ( 4 ) , neuroblastoma ( 1 ) , melanoma skin cancer ( 9 )
Relevant cell line - cell type - tissue:
'neuron, cortical' ( 1 ) , 293 (epithelial) ( 1 ) , A549 (pulmonary) ( 5 ) , BT-20 (breast cell) ( 6 ) , BT-549 (breast cell) ( 6 ) , Calu 6 (pulmonary) ( 6 ) , Flp-In T-Rex-293 (epithelial) [PRKD1 (human), genetic knockin] ( 7 ) , Flp-In T-Rex-293 (epithelial) ( 7 ) , H2009 (pulmonary) ( 6 ) , H2077 (pulmonary) ( 6 ) , H2887 (pulmonary) ( 6 ) , H322M (pulmonary) ( 6 ) , HCC1359 (pulmonary) ( 6 ) , HCC1937 (breast cell) ( 6 ) , HCC2279 (pulmonary) ( 6 ) , HCC366 (pulmonary) ( 6 ) , HCC4006 (pulmonary) ( 6 ) , HCC78 (pulmonary) ( 6 ) , HCC827 (pulmonary) ( 6 ) , HeLa (cervical) ( 8 ) , HMLER ('stem, breast cancer') [CXCR4 (human), knockdown] ( 2 ) , HMLER ('stem, breast cancer') ( 2 ) , HOP62 (pulmonary) ( 6 ) , LCLC-103H (pulmonary) ( 6 ) , lung ( 4 ) , MCF-7 (breast cell) ( 6 ) , MDA-MB-231 (breast cell) ( 6 ) , MDA-MB-468 (breast cell) ( 6 ) , NCI-H1395 (pulmonary) ( 6 ) , NCI-H1568 (pulmonary) ( 6 ) , NCI-H157 (pulmonary) ( 6 ) , NCI-H1648 (pulmonary) ( 6 ) , NCI-H1666 (pulmonary) ( 6 ) , NCI-H2030 (pulmonary) ( 6 ) , NCI-H2172 (pulmonary) ( 6 ) , NCI-H322 (pulmonary) ( 6 ) , NCI-H520 (squamous) ( 6 ) , NCI-H647 (pulmonary) ( 6 ) , PC9 (pulmonary) ( 6 ) , SH-SY5Y (neural crest) ( 1 , 3 ) , skin ( 9 )

Upstream Regulation
Putative in vivo kinases:
CDK5 (human) ( 1 )

Downstream Regulation
Effects of modification on CRMP-2 iso3:
molecular association, regulation ( 1 ) , protein degradation ( 1 ) , protein stabilization ( 1 )
Effects of modification on biological processes:
cell growth, induced ( 1 )
Induce interaction with:
PIN1 (human) ( 1 )

References 

1

Balastik M, et al. (2015) Prolyl Isomerase Pin1 Regulates Axon Guidance by Stabilizing CRMP2A Selectively in Distal Axons. Cell Rep 13, 812-28
26489457   Curated Info

2

Yi T, et al. (2014) Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells. Proc Natl Acad Sci U S A 111, E2182-90
24782546   Curated Info

3

Luerman GC, et al. (2014) Phosphoproteomic evaluation of pharmacological inhibition of leucine-rich repeat kinase 2 reveals significant off-target effects of LRRK-2-IN-1. J Neurochem 128, 561-76
24117733   Curated Info

4

Schweppe DK, Rigas JR, Gerber SA (2013) Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors. J Proteomics 91, 286-96
23911959   Curated Info

5

Kim JY, et al. (2013) Dissection of TBK1 signaling via phosphoproteomics in lung cancer cells. Proc Natl Acad Sci U S A 110, 12414-9
23836654   Curated Info

6

Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68
22617229   Curated Info

7

Franz-Wachtel M, et al. (2012) Global detection of protein kinase D-dependent phosphorylation events in nocodazole-treated human cells. Mol Cell Proteomics 11, 160-70
22496350   Curated Info

8

Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5
21712546   Curated Info

9

Tucker M (2009) CST Curation Set: 6416; Year: 2009; Biosample/Treatment: tissue, skin/untreated; Disease: melanoma skin cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-Akt Substrate (RXRXXS/T) (110B7) Rabbit mAb Cat#: 9614, PTMScan(R) Phospho-Akt Substrate Motif (RXXS*/T*) Immunoaffinity Beads Cat#: 1978
Curated Info

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