Ser348
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Home > Phosphorylation Site Page: > Ser348  -  TREK-1 (mouse)

Site Information
KETRRRLsVEIYDKF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 456161

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 , 3 ) , microscopy-colocalization with upstream kinase ( 6 ) , mutation of modification site ( 4 , 5 , 6 , 7 , 8 ) , western blotting ( 6 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 5 ) , brain ( 2 , 3 ) , CHO (fibroblast) ( 4 ) , COS (fibroblast) ( 6 , 8 ) , neuron-'brain, hippocampus' ( 7 ) , oocyte ( 7 , 8 )

Upstream Regulation
Regulatory protein:
mGluR4 (human) ( 4 )
Treatments:
bisindolylmaleimide ( 4 ) , H-89 ( 4 ) , KT5720 ( 4 ) , KT5823 ( 4 ) , L-AP4 ( 4 ) , okadaic_acid ( 4 )

Downstream Regulation
Effects of modification on TREK-1:
activity, induced ( 7 ) , activity, inhibited ( 4 , 5 , 8 )
Effects of modification on biological processes:
cytoskeletal reorganization ( 6 )

References 

1

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

2

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

3

Wiśniewski JR, et al. (2010) Brain phosphoproteome obtained by a FASP-based method reveals plasma membrane protein topology. J Proteome Res 9, 3280-9
20415495   Curated Info

4

Cain SM, Meadows HJ, Dunlop J, Bushell TJ (2008) mGlu4 potentiation of K(2P)2.1 is dependant on C-terminal dephosphorylation. Mol Cell Neurosci 37, 32-9
17916432   Curated Info

5

Murbartián J, Lei Q, Sando JJ, Bayliss DA (2005) Sequential phosphorylation mediates receptor- and kinase-induced inhibition of TREK-1 background potassium channels. J Biol Chem 280, 30175-84
16006563   Curated Info

6

Lauritzen I, et al. (2005) Cross-talk between the mechano-gated K2P channel TREK-1 and the actin cytoskeleton. EMBO Rep 6, 642-8
15976821   Curated Info

7

Bockenhauer D, Zilberberg N, Goldstein SA (2001) KCNK2: reversible conversion of a hippocampal potassium leak into a voltage-dependent channel. Nat Neurosci 4, 486-91
11319556   Curated Info

8

Maingret F, et al. (2000) TREK-1 is a heat-activated background K(+) channel. EMBO J 19, 2483-91
10835347   Curated Info