Ser315
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Home > Phosphorylation Site Page: > Ser315  -  TREK-1 (mouse)

Site Information
GDWLRVIsKKTKEEV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 456160

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 , 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
mGluR4 (human) ( 2 )
Treatments:
bisindolylmaleimide ( 2 ) , H-89 ( 2 ) , KT5720 ( 2 ) , KT5823 ( 2 ) , L-AP4 ( 2 ) , okadaic_acid ( 2 )

Downstream Regulation
Effects of modification on TREK-1:
activity, induced ( 1 ) , activity, inhibited ( 2 , 3 )

References 

1

Bagriantsev SN, Clark KA, Minor DL (2012) Metabolic and thermal stimuli control K(2P)2.1 (TREK-1) through modular sensory and gating domains. EMBO J 31, 3297-308
22728824   Curated Info

2

Cain SM, Meadows HJ, Dunlop J, Bushell TJ (2008) mGlu4 potentiation of K(2P)2.1 is dependant on C-terminal dephosphorylation. Mol Cell Neurosci 37, 32-9
17916432   Curated Info

3

Murbartián J, Lei Q, Sando JJ, Bayliss DA (2005) Sequential phosphorylation mediates receptor- and kinase-induced inhibition of TREK-1 background potassium channels. J Biol Chem 280, 30175-84
16006563   Curated Info