Thr313
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Home > Phosphorylation Site Page: > Thr313  -  PINK1 (human)

Site Information
EGLGHGRtLFLVMkN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 23003808

In vivo Characterization
Methods used to characterize site in vivo:
2D analysis ( 1 ) , immunoprecipitation ( 1 ) , mass spectrometry ( 1 ) , microscopy-colocalization with upstream kinase ( 1 ) , mutation of modification site ( 1 ) , phosphopeptide mapping ( 1 ) , western blotting ( 1 )
Disease tissue studied:
adrenal cancer ( 1 ) , pheochromocytoma ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , CHO (fibroblast) ( 1 ) , PC-12 (chromaffin) ( 1 ) , SF9 ( 1 )

Upstream Regulation
Putative in vivo kinases:
MARK2 (human) ( 1 )
Kinases, in vitro:
MARK2 (human) ( 1 )

Downstream Regulation
Effects of modification on PINK1:
enzymatic activity, induced ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
Parkinson's disease ( 1 )

References 

1

Matenia D, et al. (2012) Microtubule affinity-regulating kinase 2 (MARK2) turns on phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1) at Thr-313, a mutation site in Parkinson disease: effects on mitochondrial transport. J Biol Chem 287, 8174-86
22238344   Curated Info

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