Ser358
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Home > Phosphorylation Site Page: > Ser358  -  MLKL (human)

Site Information
ELRkTQtsMSLGTtR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 22996309

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 5 ) , immunoprecipitation ( 4 ) , mutation of modification site ( 5 ) , phospho-antibody ( 3 , 4 , 5 ) , western blotting ( 4 , 5 )
Disease tissue studied:
Alzheimer's disease ( 3 ) , colorectal cancer ( 4 , 5 ) , colorectal carcinoma ( 4 , 5 ) , lymphoma ( 5 )
Relevant cell line - cell type - tissue:
brain ( 3 ) , HeLa (cervical) ( 5 ) , HT-29 (intestinal) ( 4 , 5 ) , liver ( 5 ) , U-937 (myeloid) ( 5 )

Upstream Regulation
Putative in vivo kinases:
RIPK3 (human) ( 5 , 6 )
Treatments:
LPS ( 5 ) , Necrostatin-1 ( 5 ) , TNF ( 5 ) , Z-VAD-FMK ( 5 )

Downstream Regulation
Effects of modification on MLKL:
intracellular localization ( 3 , 4 , 5 ) , molecular association, regulation ( 5 ) , protein conformation ( 3 , 4 , 5 )
Effects of modification on biological processes:
apoptosis, induced ( 5 )
Induce interaction with:
KDELC1 (human) ( 5 ) , LAMP1 (human) ( 5 ) , TOM20 (human) ( 5 )

Disease / Diagnostics Relevance
Relevant diseases:
Alzheimer's disease ( 3 )

References 

1

Moerke C, et al. (2018) The anticonvulsive Phenhydan suppresses extrinsic cell death. Cell Death Differ
30442947   Curated Info

2

Han Q, et al. (2018) Resibufogenin suppresses colorectal cancer growth and metastasis through RIP3-mediated necroptosis. J Transl Med 16, 201
30029665   Curated Info

3

Caccamo A, et al. (2017) Necroptosis activation in Alzheimer's disease. Nat Neurosci 20, 1236-1246
28758999   Curated Info

4

Yoon S, Bogdanov K, Kovalenko A, Wallach D (2016) Necroptosis is preceded by nuclear translocation of the signaling proteins that induce it. Cell Death Differ 23, 253-60
26184911   Curated Info

5

Wang H, et al. (2014) Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3. Mol Cell 54, 133-46
24703947   Curated Info

6

Sun L, et al. (2012) Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell 148, 213-27
22265413   Curated Info