Ser367
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Home > Phosphorylation Site Page: > Ser367  -  TRF1 (human)

Site Information
SRIPVSKsQPVtPEK   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 22996308

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 2 ) , immunoprecipitation ( 2 ) , mass spectrometry ( 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Disease tissue studied:
fibrosarcoma of soft tissue ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
ATM (human) ( 2 )
Kinases, in vitro:
ATM (human) ( 2 )
Treatments:
KU-55933 ( 2 ) , MG132 ( 2 ) , NU7026 ( 2 )

Downstream Regulation
Effects of modification on TRF1:
intracellular localization ( 1 , 2 ) , molecular association, regulation ( 2 ) , protein degradation ( 2 )
Inhibit interaction with:
DNA ( 2 )

References 

1

Tong AS, et al. (2015) ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres. Cell Rep 13, 1633-46
26586433   Curated Info

2

McKerlie M, Lin S, Zhu XD (2012) ATM regulates proteasome-dependent subnuclear localization of TRF1, which is important for telomere maintenance. Nucleic Acids Res 40, 3975-89
22266654   Curated Info