Ser463

Site Information
CNQDERIskLEQQMA SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 22996300

In vivo Characterization
Methods used to characterize site in vivo:	[32P] bio-synthetic labeling ( 2 ) , immunoprecipitation ( 2 ) , mutation of modification site ( 1 , 2 ) , phosphopeptide mapping ( 1 )
Disease tissue studied:	brain cancer ( 1 ) , glioblastoma multiforme ( 1 ) , glioma ( 1 )
Relevant cell line - cell type - tissue:	293 (epithelial) ( 2 ) , HEK293T (epithelial) ( 2 ) , U373 MG (glial) ( 1 )

Downstream Regulation
Effects of modification on biological processes:	cell adhesion, induced ( 1 ) , cell growth, inhibited ( 1 ) , cell motility, inhibited ( 2 ) , cytoskeletal reorganization ( 1 , 2 )

References
1	Ziemann A, et al. (2013) CRN2 enhances the invasiveness of glioblastoma cells. Neuro Oncol 15, 548-61 23410663 Curated Info
2	Xavier CP, et al. (2012) Phosphorylation of CRN2 by CK2 regulates F-actin and Arp2/3 interaction and inhibits cell migration. Sci Rep 2, 241 22355754 Curated Info