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Site Information |
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QKDKFLQtFCGSPLY SwissProt Entrez-Gene |
Blast this site against: NCBI SwissProt PDB |
Site Group ID: 456032 |
Available spectra: 2 CST |
In vivo Characterization | |
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Methods used to characterize site in vivo: | |
Disease tissue studied: | |
Relevant cell line - cell type - tissue: |
Upstream Regulation | |
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Putative in vivo kinases: | |
Kinases, in vitro: | |
Phosphatases, in vitro: | |
Treatments: |
Downstream Regulation | |
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Effects of modification on NuaK1: | |
Effects of modification on biological processes: |
References | |
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Rikova K, Hall B (2013) CST Curation Set: 20742, 21169, 30176, 30177, 30178; Year: 2013; Biosample/Treatment: cell line, H838, DMS153, H2073, H209, H1437; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY, p[ST], RXXp[ST], pSQ, p[ST]QG, LXRXXp[ST], p[ST]P
Curated Info |
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Hou X, et al. (2011) A new role of NUAK1: directly phosphorylating p53 and regulating cell proliferation. Oncogene 30, 2933-42
21317932 Curated Info |
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Humbert N, et al. (2010) Regulation of ploidy and senescence by the AMPK-related kinase NUAK1. EMBO J 29, 376-86
19927127 Curated Info |
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Zagórska A, et al. (2010) New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion. Sci Signal 3, ra25
20354225 Curated Info |
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Oppermann FS, et al. (2009) Large-scale proteomics analysis of the human kinome. Mol Cell Proteomics 8, 1751-64
19369195 Curated Info |
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Suzuki A, Ogura T, Esumi H (2006) NDR2 acts as the upstream kinase of ARK5 during insulin-like growth factor-1 signaling. J Biol Chem 281, 13915-21
16488889 Curated Info |
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Lizcano JM, et al. (2004) LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. EMBO J 23, 833-43
14976552 Curated Info |