Tyr565
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Home > Phosphorylation Site Page: > Tyr565  -  PKCD (mouse)

Site Information
IRVDTPHyPRWITKE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447576

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
keratinocyte ( 1 )

Upstream Regulation
Kinases, in vitro:
LYN (human) ( 2 )
Treatments:
PD173074 ( 1 )

Downstream Regulation
Effects of modification on PKCD:
enzymatic activity, inhibited ( 1 )
Effects of modification on biological processes:
carcinogenesis, inhibited ( 1 )

References 

1

Joseloff E, et al. (2002) Src family kinases phosphorylate protein kinase C delta on tyrosine residues and modify the neoplastic phenotype of skin keratinocytes. J Biol Chem 277, 12318-23
11812791   Curated Info

2

Szallasi Z, et al. (1995) Development of a rapid approach to identification of tyrosine phosphorylation sites: application to PKC delta phosphorylated upon activation of the high affinity receptor for IgE in rat basophilic leukemia cells. Biochem Biophys Res Commun 214, 888-94
7575560   Curated Info