Tyr187
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Home > Phosphorylation Site Page: > Tyr187  -  PKCD (mouse)

Site Information
WGLNkQGyKCRQCNA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447579

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 , 3 , 4 ) , phospho-antibody ( 1 , 2 , 3 ) , phosphopeptide mapping ( 4 ) , western blotting ( 3 )
Disease tissue studied:
brain cancer ( 1 , 2 , 3 ) , glioblastoma ( 1 , 2 , 3 ) , glioma ( 1 , 2 , 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
Src (mouse) ( 3 )
Treatments:
etoposide ( 2 ) , PDGF ( 3 , 4 ) , phorbol_ester ( 3 , 4 ) , PP1 ( 3 ) , PP2 ( 3 ) , TRAIL ( 1 )

Downstream Regulation
Effects of modification on PKCD:
intracellular localization ( 3 ) , molecular association, regulation ( 3 )
Effects of modification on biological processes:
apoptosis, induced ( 2 ) , transcription, altered ( 3 )
Induce interaction with:
Fyn (mouse) ( 3 )

References 

1

Okhrimenko H, et al. (2005) Roles of tyrosine phosphorylation and cleavage of protein kinase Cdelta in its protective effect against tumor necrosis factor-related apoptosis inducing ligand-induced apoptosis. J Biol Chem 280, 23643-52
15774464   Curated Info

2

Blass M, et al. (2002) Tyrosine phosphorylation of protein kinase Cdelta is essential for its apoptotic effect in response to etoposide. Mol Cell Biol 22, 182-95
11739733   Curated Info

3

Kronfeld I, et al. (2000) Phosphorylation of protein kinase Cdelta on distinct tyrosine residues regulates specific cellular functions. J Biol Chem 275, 35491-8
10945993   Curated Info

4

Li W, et al. (1996) Identification of tyrosine 187 as a protein kinase C-delta phosphorylation site. J Biol Chem 271, 26404-9
8824297   Curated Info