Tyr155
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Home > Phosphorylation Site Page: > Tyr155  -  PKCD (mouse)

Site Information
IKQAKIHyIKNHEFI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447575

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 , 3 , 4 , 5 , 6 ) , phospho-antibody ( 2 , 4 , 5 ) , western blotting ( 2 , 5 , 6 )
Disease tissue studied:
brain cancer ( 4 , 5 ) , glioblastoma ( 4 , 5 ) , glioma ( 4 , 5 )
Relevant cell line - cell type - tissue:
3T3 (fibroblast) ( 6 ) , A172 (glial) ( 4 ) , bone marrow ( 1 ) , C6 (glial) ( 5 ) , endothelial ( 1 ) , HEK293T (epithelial) ( 2 ) , lung ( 1 ) , neutrophil ( 1 ) , ParC5 ( 3 ) , parotid acinar-salivary gland ( 3 )

Upstream Regulation
Putative in vivo kinases:
Src (mouse) ( 5 )
Kinases, in vitro:
LYN (human) ( 7 )
Treatments:
etoposide ( 3 ) , H2O2 ( 2 ) , PDGF ( 5 , 6 ) , phorbol_ester ( 3 , 5 , 6 ) , PP1 ( 5 ) , PP2 ( 5 ) , TRAIL ( 4 )

Downstream Regulation
Effects of modification on PKCD:
intracellular localization ( 3 , 4 , 5 ) , molecular association, regulation ( 2 ) , protein degradation ( 4 )
Effects of modification on biological processes:
apoptosis, induced ( 3 ) , apoptosis, inhibited ( 4 ) , cell adhesion, induced ( 1 ) , cell cycle regulation ( 5 ) , cell growth, altered ( 6 ) , cell motility, induced ( 1 )
Induce interaction with:
KPNA2 (human) ( 2 )

References 

1

Soroush F, et al. (2018) Protein Kinase C-Delta (PKCδ) Tyrosine Phosphorylation is a Critical Regulator of Neutrophil-Endothelial Cell Interaction in Inflammation. Shock
30095599   Curated Info

2

Adwan TS, et al. (2011) Regulated binding of importin-α to protein kinase Cδ in response to apoptotic signals facilitates nuclear import. J Biol Chem 286, 35716-24
21865164   Curated Info

3

Humphries MJ, et al. (2008) Tyrosine phosphorylation regulates nuclear translocation of PKCdelta. Oncogene 27, 3045-53
18059334   Curated Info

4

Okhrimenko H, et al. (2005) Roles of tyrosine phosphorylation and cleavage of protein kinase Cdelta in its protective effect against tumor necrosis factor-related apoptosis inducing ligand-induced apoptosis. J Biol Chem 280, 23643-52
15774464   Curated Info

5

Kronfeld I, et al. (2000) Phosphorylation of protein kinase Cdelta on distinct tyrosine residues regulates specific cellular functions. J Biol Chem 275, 35491-8
10945993   Curated Info

6

Acs P, et al. (2000) Effect of a tyrosine 155 to phenylalanine mutation of protein kinase cdelta on the proliferative and tumorigenic properties of NIH 3T3 fibroblasts. Carcinogenesis 21, 887-91
10783308   Curated Info

7

Szallasi Z, et al. (1995) Development of a rapid approach to identification of tyrosine phosphorylation sites: application to PKC delta phosphorylated upon activation of the high affinity receptor for IgE in rat basophilic leukemia cells. Biochem Biophys Res Commun 214, 888-94
7575560   Curated Info