Ser621
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Home > Phosphorylation Site Page: > Ser621  -  Lu (human)

Site Information
sGGARGGsGGFGDEC   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455912

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 7 ) , mass spectrometry ( 2 , 3 , 4 , 5 ) , mutation of modification site ( 1 , 7 )
Disease tissue studied:
breast cancer ( 3 , 4 ) , breast ductal carcinoma ( 4 ) , luminal A breast cancer ( 2 ) , luminal B breast cancer ( 2 ) , colorectal cancer ( 1 ) , colorectal carcinoma ( 1 ) , leukemia ( 7 ) , chronic myelogenous leukemia ( 7 ) , lung cancer ( 5 ) , non-small cell lung adenocarcinoma ( 5 )
Relevant cell line - cell type - tissue:
breast ( 2 , 4 ) , BT-474 (breast cell) ( 3 ) , K562 (erythroid) ( 7 ) , lung ( 5 ) , MDCK (epithelial) ( 1 , 7 )

Upstream Regulation
Putative in vivo kinases:
PKACA (human) ( 1 , 7 )
Treatments:
Akt-I-1 ( 1 ) , cAMP_analog ( 7 ) , DMSO ( 1 ) , H-89 ( 1 )

Downstream Regulation
Effects of modification on Lu:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
cell adhesion, altered ( 7 ) , cell adhesion, induced ( 1 ) , cell motility, induced ( 1 )
Induce interaction with:
Lu (human) ( 1 )

References 

1

Guadall A, et al. (2019) Dimerization and phosphorylation of Lutheran/basal cell adhesion molecule are critical for its function in cell migration on laminin. J Biol Chem
31413112   Curated Info

2

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

3

Carrier M, et al. (2016) Phosphoproteome and Transcriptome of RA-Responsive and RA-Resistant Breast Cancer Cell Lines. PLoS One 11, e0157290
27362937   Curated Info

4

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

5

Schweppe DK, Rigas JR, Gerber SA (2013) Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors. J Proteomics 91, 286-96
23911959   Curated Info

6

Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21
23312004   Curated Info

7

Gauthier E, et al. (2005) Protein kinase A-dependent phosphorylation of Lutheran/basal cell adhesion molecule glycoprotein regulates cell adhesion to laminin alpha5. J Biol Chem 280, 30055-62
15975931   Curated Info