Thr155
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Home > Phosphorylation Site Page: > Thr155  -  p53 (human)

Site Information
DstPPPGtRVRAMAI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455908

In vivo Characterization
Methods used to characterize site in vivo:
flow cytometry ( 1 ) , immunoprecipitation ( 1 , 2 , 4 ) , mutation of modification site ( 1 , 2 , 4 ) , phospho-antibody ( 1 , 2 , 4 ) , western blotting ( 1 , 2 , 4 )
Disease tissue studied:
bone cancer ( 1 ) , breast cancer ( 4 ) , lung cancer ( 1 ) , non-small cell lung cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
COPS5 (human) ( 1 )
Kinases, in vitro:
CK2A1 (human) ( 3 , 4 )
Treatments:
adriamycin ( 2 ) , MG132 ( 1 ) , PUGNAc ( 2 ) , streptozotocin ( 2 )

Downstream Regulation
Effects of modification on p53:
molecular association, regulation ( 1 ) , protein degradation ( 1 , 2 , 3 , 4 ) , ubiquitination ( 1 )
Effects of modification on biological processes:
apoptosis, induced ( 1 ) , cell cycle regulation ( 1 ) , cell growth, inhibited ( 1 ) , transcription, induced ( 1 )
Induce interaction with:
FBXO42 (human) ( 1 ) , MDM2 (human) ( 4 )

References 

1

Sun L, et al. (2011) Substrate phosphorylation and feedback regulation in JFK-promoted p53 destabilization. J Biol Chem 286, 4226-35
21127074   Curated Info

2

Yang WH, et al. (2006) Modification of p53 with O-linked N-acetylglucosamine regulates p53 activity and stability. Nat Cell Biol 8, 1074-83
16964247   Curated Info

3

Uhle S, et al. (2003) Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome. EMBO J 22, 1302-12
12628923   Curated Info

4

Bech-Otschir D, et al. (2001) COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system. EMBO J 20, 1630-9
11285227   Curated Info