Ser185
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Home > Phosphorylation Site Page: > Ser185  -  C/EBP-beta (rat)

Site Information
LSTsSSSsPPGtPSP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455886

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 2 ) , electrophoretic mobility shift ( 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 2 ) , phosphopeptide mapping ( 2 ) , western blotting ( 2 )
Disease tissue studied:
bone cancer ( 2 )
Relevant cell line - cell type - tissue:
L cells (fibroblast) ( 1 ) , UMR106 (bone cell) ( 2 )

Upstream Regulation
Putative in vivo kinases:
GSK3B (human) ( 2 )
Kinases, in vitro:
GSK3B (human) ( 2 )

Downstream Regulation
Effects of modification on biological processes:
transcription, altered ( 2 )
Induce interaction with:
DNA ( 2 )

References 

1

Lee S, et al. (2010) RSK-mediated phosphorylation in the C/EBP{beta} leucine zipper regulates DNA binding, dimerization, and growth arrest activity. Mol Cell Biol 30, 2621-35
20351173   Curated Info

2

Zhao X, et al. (2005) Cyclic GMP-dependent protein kinase regulates CCAAT enhancer-binding protein beta functions through inhibition of glycogen synthase kinase-3. J Biol Chem 280, 32683-92
16055922   Curated Info