Ser380
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Home > Phosphorylation Site Page: > Ser380  -  MSK1 (mouse)

Site Information
GysFVAPsILFKRNA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455795

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 , 3 , 4 , 5 , 6 ) , peptide sequencing ( 6 ) , western blotting ( 6 )
Relevant cell line - cell type - tissue:
'3T3-L1, differentiated' (adipocyte) ( 1 ) , 293 (epithelial) ( 6 ) , 32Dcl3 (myeloid) [FLT3 (mouse), transfection, chimera with human FLT3-ITD mutant (corresponding to wild type P36888 ( 5 ) , 32Dcl3 (myeloid) ( 5 ) , embryo ( 2 ) , liver ( 2 , 3 ) , macrophage-bone marrow ( 4 ) , macrophage-bone marrow [DUSP1 (mouse), homozygous knockout] ( 4 )

Upstream Regulation
Treatments:
insulin ( 1 ) , LPS ( 4 )

References 

1

Humphrey SJ, et al. (2013) Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2. Cell Metab 17, 1009-20
23684622   Curated Info

2

Stokes MP, et al. (2012) PTMScan Direct: Identification and Quantification of Peptides from Critical Signaling Proteins by Immunoaffinity Enrichment Coupled with LC-MS/MS. Mol Cell Proteomics 11, 187-201
22322096   Curated Info

3

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

4

Weintz G, et al. (2010) The phosphoproteome of toll-like receptor-activated macrophages. Mol Syst Biol 6, 371
20531401   Curated Info

5

Choudhary C, et al. (2009) Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes. Mol Cell 36, 326-39
19854140   Curated Info

6

McCoy CE, et al. (2007) Identification of novel phosphorylation sites in MSK1 by precursor ion scanning MS. Biochem J 402, 491-501
17117922   Curated Info