Ser496
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Home > Phosphorylation Site Page: > Ser496  -  ERK5 (human)

Site Information
SRLRDGPsAPLEAPE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455518

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 2 ) , mass spectrometry ( 3 ) , mass spectrometry (in vitro) ( 4 ) , mutation of modification site ( 4 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
HER2 positive breast cancer ( 3 ) , breast cancer, triple negative ( 3 ) , thyroid cancer ( 2 )
Relevant cell line - cell type - tissue:
breast ( 3 ) , macrophage-bone marrow ( 1 ) , monocyte-blood ( 1 ) , myocyte-heart ( 4 )

Upstream Regulation
Putative in vivo kinases:
p90RSK (human) ( 4 )
Kinases, in vitro:
ERK5 (human) ( 4 , 5 )
Treatments:
atazanavir ( 1 ) , cART ( 1 ) , FMK-MEA ( 1 ) , H2O2 ( 1 ) , Maraviroc ( 1 ) , ritonavir ( 1 ) , Tenofovir ( 1 )

Downstream Regulation
Effects of modification on biological processes:
apoptosis, induced ( 4 ) , transcription, inhibited ( 1 )

References 

1

Singh MV, et al. (2018) Senescent Phenotype Induced by p90RSK-NRF2 Signaling Sensitizes Monocytes and Macrophages to Oxidative Stress in HIV Individuals: Implications for Atherogenesis. Circulation
30586719   Curated Info

2

Ye F, et al. (2018) Whole exome and target sequencing identifies MAP2K5 as novel susceptibility gene for familial non-medullary thyroid carcinoma. Int J Cancer
30132833   Curated Info

3

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

4

Le NT, et al. (2012) p90RSK Targets the ERK5-CHIP Ubiquitin E3 Ligase Activity in Diabetic Hearts and Promotes Cardiac Apoptosis and Dysfunction. Circ Res 110, 536-50
22267842   Curated Info

5

Mody N, et al. (2003) An analysis of the phosphorylation and activation of extracellular-signal-regulated protein kinase 5 (ERK5) by mitogen-activated protein kinase kinase 5 (MKK5) in vitro. Biochem J 372, 567-75
12628002   Curated Info