Thr451
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Home > Phosphorylation Site Page: > Thr451  -  FOXO4 (human)

Site Information
PIPKALGtPVLtPPt   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448518

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 2 , 3 ) , mass spectrometry (in vitro) ( 1 ) , mutation of modification site ( 2 , 3 ) , phospho-antibody ( 1 , 2 ) , phosphoamino acid analysis ( 3 ) , phosphopeptide mapping ( 3 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
BRAF (human) ( 1 )
Putative in vivo kinases:
JNK1 (human) ( 2 ) , JNK2 (human) ( 2 )
Kinases, in vitro:
JNK1 (human) ( 1 , 2 )
Treatments:
H2O2 ( 2 )

Downstream Regulation
Effects of modification on FOXO4:
intracellular localization ( 2 )
Effects of modification on biological processes:
cell cycle regulation ( 3 ) , transcription, induced ( 2 , 3 )

References 

1

de Keizer PL, et al. (2010) Activation of forkhead box O transcription factors by oncogenic BRAF promotes p21cip1-dependent senescence. Cancer Res 70, 8526-36
20959475   Curated Info

2

Essers MA, et al. (2004) FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK. EMBO J 23, 4802-12
15538382   Curated Info

3

De Ruiter ND, Burgering BM, Bos JL (2001) Regulation of the Forkhead transcription factor AFX by Ral-dependent phosphorylation of threonines 447 and 451. Mol Cell Biol 21, 8225-35
11689711   Curated Info