Thr207
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Home > Phosphorylation Site Page: > Thr207  -  RIP140 (mouse)

Site Information
GPtLPDVtPNLIRDS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455626

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 2 , 3 , 4 ) , mutation of modification site ( 1 , 3 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
3T3-L1 (fibroblast) ( 1 ) , COS (fibroblast) ( 1 ) , Sf21 [RIP140 (mouse)] ( 4 )

Upstream Regulation
Putative in vivo kinases:
ERK2 (mouse) ( 1 )
Treatments:
siRNA ( 1 )

Downstream Regulation
Effects of modification on RIP140:
acetylation ( 1 ) , activity, induced ( 3 ) , intracellular localization ( 1 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:
cell differentiation, induced ( 1 ) , transcription, inhibited ( 1 )
Induce interaction with:
p300 (mouse) ( 1 )

References 

1

Ho PC, et al. (2008) Modulation of lysine acetylation-stimulated repressive activity by Erk2-mediated phosphorylation of RIP140 in adipocyte differentiation. Cell Signal 20, 1911-9
18655826   Curated Info

2

Mostaqul Huq MD, Gupta P, Wei LN (2008) Post-translational modifications of nuclear co-repressor RIP140: a therapeutic target for metabolic diseases. Curr Med Chem 15, 386-92
18288993   Curated Info

3

Gupta P, et al. (2005) Regulation of co-repressive activity of and HDAC recruitment to RIP140 by site-specific phosphorylation. Mol Cell Proteomics 4, 1776-84
16093479   Curated Info

4

Huq MD, Khan SA, Park SW, Wei LN (2005) Mapping of phosphorylation sites of nuclear corepressor receptor interacting protein 140 by liquid chromatography-tandem mass spectroscopy. Proteomics 5, 2157-66
15846843   Curated Info

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