Ser401
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.7.5
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser401  -  GATA2 (human)

Site Information
QTRNRKMsNKSKKSK   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455583

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 2 ) , electrophoretic mobility shift ( 2 ) , mutation of modification site ( 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
'stem, hematopoietic' ( 1 ) , 293 (epithelial) ( 2 ) , 3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] ( 2 )

Upstream Regulation
Regulatory protein:
Klotho (human) ( 1 ) , SLC20A1 (human) ( 1 )
Kinases, in vitro:
Akt1 (human) ( 2 )
Treatments:
insulin ( 2 ) , MK-2206 ( 1 ) , sodium_phosphate ( 1 ) , wortmannin ( 2 )

Downstream Regulation
Effects of modification on GATA2:
activity, inhibited ( 2 ) , intracellular localization ( 2 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:
cell differentiation, induced ( 1 ) , cell growth, altered ( 2 ) , cell growth, induced ( 1 ) , transcription, altered ( 2 ) , transcription, induced ( 1 )
Induce interaction with:
FOG1 (human) ( 1 )

References 

1

Du C, et al. (2022) Renal Klotho and inorganic phosphate are extrinsic factors that antagonistically regulate hematopoietic stem cell maintenance. Cell Rep 38, 110392
35172146   Curated Info

2

Menghini R, et al. (2005) Phosphorylation of GATA2 by Akt increases adipose tissue differentiation and reduces adipose tissue-related inflammation: a novel pathway linking obesity to atherosclerosis. Circulation 111, 1946-53
15837948   Curated Info

Developed with grants from  NIH Logo and literature mining with Linguamatics  I2E Logo Creative Commons License PhosphoSite, created by Cell Signaling Technology is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License.

©2003-2024 Cell Signaling Technology, Inc.