Thr490
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Home > Phosphorylation Site Page: > Thr490  -  RAG2 (human)

Site Information
EIARALHtPQRVLPL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455560

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 ) , 63-12 ('B lymphocyte, precursor') ( 2 ) , HeLa (cervical) ( 2 ) , thymocyte ( 1 )

Downstream Regulation
Effects of modification on RAG2:
molecular association, regulation ( 2 ) , protein degradation ( 2 ) , ubiquitination ( 2 )
Effects of modification on biological processes:
carcinogenesis, altered ( 1 )
Induce interaction with:
SKP2 (human) ( 2 )

Disease / Diagnostics Relevance
Relevant diseases:
B cell lymphoma ( 1 )

References 

1

Zhang L, Reynolds TL, Shan X, Desiderio S (2011) Coupling of v(d)j recombination to the cell cycle suppresses genomic instability and lymphoid tumorigenesis. Immunity 34, 163-74
21349429   Curated Info

2

Jiang H, et al. (2005) Ubiquitylation of RAG-2 by Skp2-SCF links destruction of the V(D)J recombinase to the cell cycle. Mol Cell 18, 699-709
15949444   Curated Info