Tyr343
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Home > Phosphorylation Site Page: > Tyr343  -  HOXA10 (human)

Site Information
GRkkRCPyTkHQtLE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455550

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 )
Relevant cell line - cell type - tissue:
U-937 (myeloid) ( 1 )

Upstream Regulation
Putative upstream phosphatases:
SHP-1 (human) ( 1 )
Phosphatases, in vitro:
SHP-1 (human) ( 1 )
Treatments:
IFN-gamma ( 1 )

Downstream Regulation
Effects of modification on HOXA10:
activity, inhibited ( 1 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:
transcription, induced ( 1 )
Induce interaction with:
HOXA10 (human) ( 1 )

References 

1

Eklund EA, et al. (2002) SHP1 protein-tyrosine phosphatase regulates HoxA10 DNA binding and transcriptional repression activity in undifferentiated myeloid cells. J Biol Chem 277, 36878-88
12145285   Curated Info

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