Thr723
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Home > Phosphorylation Site Page: > Thr723  -  ERK5 (mouse)

Site Information
LPPVFsGtPKGSGAG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455520

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 5 ) , mass spectrometry ( 2 , 3 , 4 ) , mutation of modification site ( 5 ) , western blotting ( 5 )
Disease tissue studied:
brain cancer ( 3 ) , neuroendocrine cancer ( 3 )
Relevant cell line - cell type - tissue:
brain ( 3 ) , COS (fibroblast) ( 5 ) , MEF (fibroblast) ( 2 ) , MEF (fibroblast) [TSC2 (mouse), homozygous knockout] ( 4 )

Upstream Regulation
Putative in vivo kinases:
ERK5 (mouse) ( 5 )
Kinases, in vitro:
ERK5 (mouse) ( 5 )

Downstream Regulation
Effects of modification on biological processes:
transcription, altered ( 5 )

References 

1

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

2

Wu X, et al. (2012) Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics 11, 1640-51
22942356   Curated Info

3

Guo A (2011) CST Curation Set: 12729; Year: 2011; Biosample/Treatment: tissue, brain/untreated; Disease: brain cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]P
Curated Info

4

Yu Y, et al. (2011) Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332, 1322-6
21659605   Curated Info

5

Morimoto H, et al. (2007) Activation of a C-terminal transcriptional activation domain of ERK5 by autophosphorylation. J Biol Chem 282, 35449-56
17928297   Curated Info