Ser30
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Home > Phosphorylation Site Page: > Ser30  -  DDIT3 (human)

Site Information
EDLQEVLssDENGGT   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455503

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 2 ) , immunoprecipitation ( 1 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
AMPKA1 (human) ( 1 )
Kinases, in vitro:
AMPKA1 (human) ( 1 ) , CK2A1 (human) ( 2 )
Treatments:
A79662 ( 1 ) , acadesine ( 1 ) , compound_C ( 1 )

Downstream Regulation
Effects of modification on DDIT3:
activity, inhibited ( 2 ) , protein degradation ( 1 ) , ubiquitination ( 1 )
Effects of modification on biological processes:
transcription, inhibited ( 2 )

References 

1

Dai X, et al. (2016) Phosphorylation of CHOP (C/EBP Homologous Protein) by the AMP-Activated Protein Kinase Alpha 1 in Macrophages Promotes CHOP Degradation and Reduces Injury-Induced Neointimal Disruption In Vivo. Circ Res 119, 1089-1100
27650555   Curated Info

2

Ubeda M, Habener JF (2003) CHOP transcription factor phosphorylation by casein kinase 2 inhibits transcriptional activation. J Biol Chem 278, 40514-20
12876286   Curated Info