Ser754
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.5.9.3
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser754  -  ERK5 (human)

Site Information
LEEFLNQsFDMGVAD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 21560206

In vivo Characterization
Methods used to characterize site in vivo:
flow cytometry ( 1 ) , immunoprecipitation ( 1 ) , mass spectrometry ( 2 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
melanoma skin cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
BRAF (human) ( 1 )
Treatments:
RO-3306 ( 1 ) , SCH772984 ( 1 )

Downstream Regulation
Effects of modification on ERK5:
intracellular localization ( 1 )
Effects of modification on biological processes:
transcription, induced ( 1 )

References 

1

Tusa I, et al. (2018) ERK5 is activated by oncogenic BRAF and promotes melanoma growth. Oncogene
29483645   Curated Info

2

Gilley R, et al. (2012) CDK1, not ERK1/2 or ERK5, is required for mitotic phosphorylation of BIM(EL). Cell Signal 24, 170-80
21924351   Curated Info