Thr504

Site Information
EAITRLVtGSQRPPD SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 455490

In vivo Characterization
Methods used to characterize site in vivo:	mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:	hepatocyte-liver ( 1 ) , liver ( 1 ) , MEF (fibroblast) [NFkB-p65 (mouse), homozygous knockout] ( 2 )

Downstream Regulation
Effects of modification on biological processes:	cell motility, inhibited ( 1 )

References
1	Moles A, et al. (2016) A RelA(p65) Thr505 phospho-site mutation reveals an important mechanism regulating NF-κB-dependent liver regeneration and cancer. Oncogene 35, 4623-32 26853469 Curated Info
2	Msaki A, et al. (2011) The role of RelA (p65) threonine 505 phosphorylation in the regulation of cell growth, survival, and migration. Mol Biol Cell 22, 3032-40 21737676 Curated Info