Thr247
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Home > Phosphorylation Site Page: > Thr247  -  RCAN1 (human)

Site Information
QtRRPEYtPIHLS__   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 21511701

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
Alzheimer's disease ( 1 ) , Down syndrome ( 1 )
Relevant cell line - cell type - tissue:
'brain, hippocampus' [DYRK1A (human), transgenic] ( 1 ) , HEK293T (epithelial) ( 1 )

Upstream Regulation
Kinases, in vitro:
DYRK1A (human) ( 1 )

Downstream Regulation
Effects of modification on RCAN1:
protein stabilization ( 1 )
Effects of modification on biological processes:
transcription, inhibited ( 1 )
Inhibit interaction with:
PPP3CA (human) ( 1 )

References 

1

Jung MS, et al. (2011) Regulation of RCAN1 protein activity by Dyrk1A protein-mediated phosphorylation. J Biol Chem 286, 40401-12
21965663   Curated Info