Tyr791
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Home > Phosphorylation Site Page: > Tyr791  -  Ret (human)

Site Information
HPHVIKLyGACSQDG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455479

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 )
Disease tissue studied:
liver cancer ( 2 ) , neuroblastoma ( 2 ) , thyroid cancer ( 2 ) , medullary thyroid carcinoma ( 2 )
Relevant cell line - cell type - tissue:

Downstream Regulation
Effects of modification on Ret:
phosphorylation ( 1 , 2 )
Effects of modification on biological processes:
transcription, altered ( 2 )

Disease / Diagnostics Relevance
Relevant diseases:
pheochromocytoma ( 1 ) , medullary thyroid carcinoma ( 2 )

References 

1

Toledo RA, et al. (2010) High penetrance of pheochromocytoma associated with the novel C634Y/Y791F double germline mutation in the RET protooncogene. J Clin Endocrinol Metab 95, 1318-27
20080836   Curated Info

2

Plaza Menacho I, et al. (2005) RET-familial medullary thyroid carcinoma mutants Y791F and S891A activate a Src/JAK/STAT3 pathway, independent of glial cell line-derived neurotrophic factor. Cancer Res 65, 1729-37
15753368   Curated Info