Ser891
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Home > Phosphorylation Site Page: > Ser891  -  Ret (human)

Site Information
EGRKMKIsDFGLSRD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455478

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 )
Disease tissue studied:
liver cancer ( 1 ) , neuroblastoma ( 1 ) , thyroid cancer ( 1 ) , medullary thyroid carcinoma ( 1 )
Relevant cell line - cell type - tissue:

Downstream Regulation
Effects of modification on Ret:
phosphorylation ( 1 )
Effects of modification on biological processes:
transcription, altered ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
medullary thyroid carcinoma ( 1 )

References 

1

Plaza Menacho I, et al. (2005) RET-familial medullary thyroid carcinoma mutants Y791F and S891A activate a Src/JAK/STAT3 pathway, independent of glial cell line-derived neurotrophic factor. Cancer Res 65, 1729-37
15753368   Curated Info