Thr165
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Home > Phosphorylation Site Page: > Thr165  -  HPK1 (human)

Site Information
ISAQIGAtLARRLsF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455473

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 2 ) , immunoprecipitation ( 1 ) , mutation of modification site ( 1 , 2 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , Jurkat (T lymphocyte) ( 2 )

Upstream Regulation
Kinases, in vitro:
HPK1 (human) ( 2 )

Downstream Regulation
Effects of modification on HPK1:
enzymatic activity, induced ( 1 , 2 ) , protein degradation ( 1 )
Effects of modification on biological processes:
transcription, altered ( 2 )

References 

1

Wang H, et al. (2014) The CUL7/F-box and WD Repeat Domain Containing 8 (CUL7/Fbxw8) Ubiquitin Ligase Promotes Degradation of Hematopoietic Progenitor Kinase 1. J Biol Chem 289, 4009-17
24362026   Curated Info

2

Arnold R, et al. (2005) Activation of hematopoietic progenitor kinase 1 involves relocation, autophosphorylation, and transphosphorylation by protein kinase D1. Mol Cell Biol 25, 2364-83
15743830   Curated Info

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