Ser491

Site Information
GSCCTIMsPGEMEKH SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 21440505

In vivo Characterization
Methods used to characterize site in vivo:	immunoprecipitation ( 3 ) , mass spectrometry ( 1 , 2 ) , mutation of modification site ( 3 ) , phospho-antibody ( 3 ) , western blotting ( 3 )
Disease tissue studied:	colorectal cancer ( 3 ) , colorectal carcinoma ( 3 )
Relevant cell line - cell type - tissue:	E.coli (bacterial) ( 3 ) , fibroblast ( 3 ) , HCT116 (intestinal) ( 3 ) , HeLa (cervical) ( 1 , 3 ) , Jurkat (T lymphocyte) ( 2 )

Downstream Regulation
Effects of modification on CDT1:	activity, inhibited ( 3 ) , molecular association, regulation ( 3 ) , protein stabilization ( 3 )
Inhibit interaction with:	RAMP (human) ( 3 )

References
1	Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94 25159151 Curated Info
2	Mertins P, et al. (2013) Integrated proteomic analysis of post-translational modifications by serial enrichment. Nat Methods 10, 634-7 23749302 Curated Info
3	Chandrasekaran S, Tan TX, Hall JR, Cook JG (2011) Stress-stimulated mitogen-activated protein kinases control the stability and activity of the cdt1 DNA replication licensing factor. Mol Cell Biol 31, 4405-16 21930785 Curated Info